Giron, from Thousand Oaks, Calif., earned a spot in the 128-player men's singles draw after becoming the school's 11th NCAA Singles Champion and first since Benjamin Kohlloeffel in 2006.
Isner is also a product of the college game, as he played at the University of Georgia from 2004-07. He is the highest ranked American player in the world at the moment at No. 15.
Giron recently completed his junior season at UCLA and opted to compete on the professional tour full time.
More information about the 2014 U.S. Open can be found HERE.